Grapefruit juice and medication: be careful with the mix

Grapefruit juice and medication: be careful with the mix

Drinking grapefruit juice while taking certain medications is contraindicated. According to a recent Canadian study, more and more products are concerned. Grapefruit indeed destroys a particular enzyme that allows the transformation and elimination of drugs. As a result, the drug is found in higher concentrations in the body.

drink
Grapefruit juice is not harmless when taking certain medications.
According to a recently released Canadian study, more and more
medications are involved. These are drugs to lower cholesterol,
hypertension or avoiding transplant rejection are concerned. (see it
complete list)

In question,
the influence that the citrus fruit has on an enzyme, cytochrome P450, an enzyme that
allows the transformation and elimination of drugs. gold grapefruit
destroys it. As a result, the drug is found in higher concentration
in the organism.

“When
we take a drug, some of it goes into the blood and has effects in
the body. We manage to foresee this influence. With grapefruit, the effects are many
more marked. When these are undesirable effects, it does damage”
explains Bruno Toussaint, the
editor of the independent journal Prescribe.

As specified
the National Medicines Safety Agency, grapefruit does not reduce the effectiveness
drugs but, by preventing its elimination, it increases the risk of overdose.
Depending on the medication, the risk of muscle damage, disorders of the
heart rate or kidney failure are amplified.

The board
is therefore simple, explains Béatrice Saint-Salvi, head of drug evaluation
to the National Medicines Safety Agency:

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